Seizures After COVID; Prenatal Benzodiazepine Exposure; New MS Framework Proposed

New seizures or epilepsy diagnoses among people who had COVID in 2020 and early 2021 were low overall after infection, but higher than in people with influenza. (Neurology)

Neuroimmune proteins can differentiate between tauopathies like Alzheimer’s, chronic traumatic encephalopathy, and progressive supranuclear palsy and may be diagnostic biomarkers. (Journal of Neuroinflammation)

Benzodiazepine exposure during pregnancy was not associated with increased risks of autism spectrum and attention-deficit/hyperactivity disorders after accounting for genetic confounding in a Taiwan cohort study. (JAMA Network Open)

A vaccine that blocked the ability of fentanyl to enter the brain showed promise in mice. (Pharmaceutics)

APOE4 genotype, amyloid-beta, and sex appeared to interact to predict tau in brain regions with high APOE mRNA expression. (Science Translational Medicine)

Among patients with cervical radiculopathy, posterior surgery was noninferior to anterior surgery on success rate and arm pain at 1 year, the FACET trial showed. (JAMA Neurology)

An international advisory committee proposed a new mechanism-driven framework for multiple sclerosis (MS) clinical trials that shifts from descriptions like relapsing-remitting and focuses on MS as a continuous disease process. (Lancet Neurology)

A herpes simplex virus antibody index was associated with tau pathology in patients with Alzheimer’s disease. (Alzheimer’s & Dementia)

Does functional neuroimaging have a role in parkinsonism and other movement disorders? (JAMA Neurology)

Severe neurologic symptoms after COVID were associated with blood-brain barrier impairment, elevated microglia activation markers, and a polyclonal B-cell response targeting self-antigens and non-self-antigens. (Nature Communications)