Insulin Degludec vs Detemir; Cooking Classes for Kids; KDIGO’s Drug Guide

Among pregnant women with type 1 diabetes, using insulin degludec was noninferior to insulin detemir for glucose control and safety. (The Lancet Diabetes & Endocrinology)

Even the lowest dose (3 mg/kg) of the investigational thyroid eye disease drug VRDN-001 significantly reduced proptosis in 67% of patients in an ongoing phase I/II trial, said developer Viridian Therapeutics.

A school-based gardening, nutrition, and cooking intervention helped cut glucose levels by 0.02% and LDL cholesterol levels by 6.40 mg/dL in youth at high risk for developing metabolic disease, according to a study of 695 children. (JAMA Network Open)

People with diabetes or obesity who consumed at least 20% of their daily calories from fast food were at significantly higher risk for liver steatosis. “The severe rise in liver fat in those with obesity or diabetes is especially striking, and probably due to the fact that these conditions cause a greater susceptibility for fat to build up in the liver,” said lead author Ani Kardashian, MD, of Keck Medicine of USC in Los Angeles, in a statement. (Clinical Gastroenterology)

England’s NHS recommended artificial pancreases for all people living with type 1 diabetes. (BBC)

“To maximize the tolerability of combination treatments, the guideline recommends the serial introduction of medications that improve intrarenal hemodynamics (such as RAS inhibitors, SGLT2 inhibitors, MRAs [mineralocorticoid receptor antagonists], diuretics, and other antihypertensive medications).” This is one of the updates in the latest clinical practice guideline from the Kidney Disease: Improving Global Outcomes (KDIGO) organization summarized in the Annals of Internal Medicine.

The protein Grb10 was identified as a potent leptin sensitizer in the brain in a mouse study, which may unlock it as a potential pathway for treating obesity. (Nature Metabolism)

People with higher levels of the bacteria Coprococcus in the gut also tended to have higher levels of insulin sensitivity. On the other hand, those with higher levels of Flavonifractor tended to have lower insulin sensitivity. (Diabetes)