Quick News Bit

IIT Delhi researchers design new strategy for development of drug molecules

0

According to the research team, they utilised tools of Organic Chemistry and Biophysics to design molecules that target protein interface.

Researchers from Indian Institute of Technology (IIT), Delhi have designed and demonstrated a new strategy for developing potential drug molecules for treating various diseases.

According to the research team, they utilised tools of Organic Chemistry and Biophysics to design molecules that target protein interface.

“Drugs are mostly organic molecules that interact with molecules present in the human body. The molecules in the body are bigger in size and are typically called macromolecules. These molecules are either proteins or nucleic acids. Presently, computer-aided rational drug discovery is utilised to find target molecule for a particular protein target. Still, this takes a considerable amount of time,” said V Haridas, Professor at IIT Delhi’s Chemistry Department.

“The researchers have come up with a chemical strategy based on the macromolecular mimicry. Molecules have shapes just like objects. Designing and synthesizing molecules with diverse shapes is an art in itself. Mimicking (copying) the macromolecular interface by uniquely shaped small molecules is an approach adopted by the research group,” he added.

They developed a universal privileged scaffold approach for the design of a variety of inhibitors. The universal scaffold could be converted to specific inhibitor for a given Protein-Protein Interaction (PPI), which makes the drug design approach relatively easier.

“We used this strategy to design drug molecules, which could be useful for treatment of Japanese Encephalitis Virus (JEV), the main cause for viral encephalitis in Southeast Asian countries, and protein aggregation diseases such as Alzheimer’s… We have also patented the JEV inhibitor drug molecule,” said Haridas.

Financial Express is now on Telegram. Click here to join our channel and stay updated with the latest Biz news and updates.

For all the latest Life Style News Click Here 

 For the latest news and updates, follow us on Google News

Read original article here

Denial of responsibility! NewsBit.us is an automatic aggregator around the global media. All the content are available free on Internet. We have just arranged it in one platform for educational purpose only. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, all materials to their authors. If you are the owner of the content and do not want us to publish your materials on our website, please contact us by email – [email protected]. The content will be deleted within 24 hours.

Leave a comment