Epstein-Barr/MS Link; How CBD Curtails Seizures; NIH Finds Rare Neurologic Disease

Mounting evidence supports a pivotal role of Epstein-Barr virus in multiple sclerosis (MS), creating opportunities for MS prevention and therapy. (Lancet Neurology)

Non-ictal allodynia predicted anti-calcitonin gene-related peptide (CGRP) therapy response in migraine patients. (Cephalalgia)

Cannabidiol (CBD), approved in a purified form (Epidiolex) to treat rare epilepsy disorders, may reduce seizures by blocking the synaptic effects of lysophosphatidylinositol and dampening a feedback loop of hyperexcitability, a mouse study suggested. (Neuron)

Lower educational quality during childhood was tied to higher dementia risk in later life. (JAMA Neurology)

Young children have differentiated brain network organization between regions that process cognitive demand and language similar to adults, functional MRIs showed. (Journal of Neuroscience)

Data from about 450 lines of stem cells cultured into motor neurons suggested that cell composition and patient sex are significant sources of variation in amyotrophic lateral sclerosis that should be controlled for in future research. (Neuron)

A functional MRI technique complemented self-reported data to inform the “reasonable person” test in law. (Science Advances)

Variation in cognitive functioning at age 54 was three times as much as variation over the next 30 years. (PLoS ONE)

Investigational leriglitazone failed to meet its primary efficacy endpoint in the ADVANCE trial of men with adrenoleukodystrophy, but secondary findings suggested the drug might have benefit. (Lancet Neurology)

NIH identified three children from two unrelated families with a rare neurologic disease associated with mutations in both copies of the ATG4D gene. (npj Genomic Medicine)