Brainwaves of a Dying Man; Omicron, MS, and COVID Vax; CRISPR Treatment Shows Effect

Electroencephalography (EEG) recordings from the dying human brain of an 87-year-old man with seizures and cardiac arrest found coordinated low- and high-frequency activity near death, which researchers speculated may represent a “last recall of life.” (Frontiers in Aging Neuroscience)

Patients with multiple sclerosis on ocrelizumab (Ocrevus) showed robust T-cell responses recognizing spike proteins from Delta and Omicron variants after mRNA COVID-19 vaccination, which increased after a third dose. (JAMA Neurology)

Researchers identified how TDP-43 protein depletion, which is associated with almost all amyotrophic lateral sclerosis (ALS) cases and half of frontotemporal dementia cases, corrupts genetic instructions for the neuronal protein UNC13A. (Nature)

Novelist Amy Bloom discussed her husband’s Alzheimer’s diagnosis and his decision to end his life. (New York Times)

An investigational CRISPR therapy reduced serum transthyretin protein by up to 93% in a phase I study of people with hereditary transthyretin amyloidosis with polyneuropathy, Intellia Therapeutics announced.

Neurofilament light had the highest accuracy in predicting neurologic outcome in people with hypoxic ischemic brain injury 48 hours after return of spontaneous circulation, a meta-analysis showed. (JAMA Neurology)

Children living in areas with higher air pollution due to fine particulate matter had an increased risk of developing ADHD. (Environmental International)

Higher stages of memory impairment using the Free and Cued Selective Reminding Test were associated with Alzheimer’s pathology in older adults with normal cognition. (Neurology)

The fractal nature of tics may help estimate tic severity and treatment effectiveness and could differentiate typical from functional tics. (Journal of the Royal Society Interface)

Around the world, doctors are seeing young patients with sudden onset of tics. Is this the first disorder spread by social media? (The Atlantic)