Brain Scans Predict Politics; Aortic Stiffness and Tau; Deep Sleep Brain Cleansing

Functional MRI brain signatures predicted political ideology, suggesting liberals and conservatives may have noticeable differences in functional connectivity. (PNAS Nexus)

New 12-month data for the investigational agent tofersen showed clinically meaningful benefit in people with SOD1-ALS, Biogen announced.

Biogen also entered into an agreement with Alectos Therapeutics to develop a novel selective GBA2 inhibitor that may be a potential disease-modifying treatment for Parkinson’s disease.

Genetic testing lowered the length of stay in the neonatal intensive care unit for infants with epilepsy. (Pediatric Neurology)

Racial and ethnic disparities in opioid use disorder prescriptions were tied to the COVID-19 pandemic. (JAMA Network Open)

Aortic stiffness, which is potentially modifiable, may be an independent target to prevent tau-related pathologies. (JAMA Neurology)

Genetic variation in sulfonylurea targets was tied to a lower risk of Alzheimer’s disease, a Mendelian randomization study showed. (Neurology)

Should research participants be told about their Alzheimer’s biomarker results? (JAMA Neurology)

Non-alcoholic fatty liver disease (NAFLD) and fibrosis were not associated with increased risk for incident dementia, and NAFLD was not associated with impaired cognitive function. (Neurology)

The FDA is extending its review of ublituximab, an investigational anti-CD20 antibody being developed for relapsing MS, to December 28, 2022, according to TG Therapeutics.

Can electric currents pulsed through the scalp help the brain flush away waste during deep sleep? (Washington Post)