One of the most significant genetic risk factors for late-onset Alzheimer’s is a form of the apolipoprotein E gene called APOE4.
A commonly used potent oral diuretic pill (approved by the U.S. Food and Drug Administration), – bumetanide, holds as a potential candidate for an Alzheimer’s disease treatment (among 1,300 known FDA-approved drugs that was tested) especially among those who are at genetic risk.
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The study team analyzed the effects of the drug through electronic health record data sets from more than 5 million people to two groups: adults over 65 who took bumetanide and a matching group who did not take bumetanide.
It was found that those who had the genetic risk and took bumetanide had a ~35% to 75% lower prevalence of Alzheimer’s disease compared to those not taking the drug.
“We know that Alzheimer’s disease will likely require specific types of treatments, perhaps multiple therapies, including some that may target an individual’s unique genetic and disease characteristics much like cancer treatments that are available today. The data in this paper make a good case to conduct a proof-of-concept trial of bumetanide in people with genetic risk,” says Jean Yuan, M.D., Ph.D., Translational Bioinformatics and Drug Development program director in the NIA Division of Neuroscience.
The team had analyzed information of gene expression signatures from a database of 213 brain tissue samples and verified the same via both mouse and human cell experiments along with the human population. The study thereby advances a precision medicine approach for genetically greater risk individuals.
“Though further tests and clinical trials are needed, this research underscores the value of big data-driven tactics combined with more traditional scientific approaches to identify existing FDA-approved drugs as candidates for drug repurposing to treat Alzheimer’s disease,” says NIA Director Richard J. Hodes, M.D.
Source: Medindia
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