Participants were 21 to 25 years of age and had completed surveys about their behaviors at ages 12, 14 and 17. Most of the teens reported overall healthy, active lifestyles, but the researchers classified two groups as having unhealthy lifestyles. One group had high body mass index scores – an approximate measure of whether a person is at a healthy weight, based on their height and body mass. The other group regularly smoked, binge-drank alcohol, and did not exercise regularly.
The team measured DNA methylation, the addition of chemical tags on DNA that can turn on or off gene expression, in blood samples taken from the participants. They used several algorithms or ‘epigenetic clocks’ – biochemical tests based on DNA methylation levels – to determine if the individuals were experiencing accelerated biological aging, and looked to see if there was any connection between unhealthy behaviors and more rapid aging.
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Overall, the clocks suggested that individuals in the two groups classified as having unhealthy behaviors were, on average, 1.7 to 3.3 years older than individuals who reported more healthy lifestyles during their adolescence. This is equivalent to aging about 2 to 3 weeks faster each calendar year. The results varied depending on which epigenetic clock they used, but the link between lifestyle and accelerated aging was primarily due to shared genetics.
“Previous studies in twins have shown that lifestyle and biological aging are largely inherited,” Kankaanp says. “Our study suggests that genetics may underlie the link between unhealthy behaviors and accelerated aging.”
The study benefits from having a large sample size, extended follow-up on participants, and the inclusion of individuals with shared genetic backgrounds. However, because the teens reported their activities themselves, the authors say that some falsely reported having healthy behaviors to appear more virtuous, which may have skewed some of the results.
More studies are needed to fully disentangle the role that genetics play in lifestyle habits and how these habits in turn affect biological aging in adolescents. Genes that contribute to obesity or substance use may directly cause accelerated biological aging, or the genes may indirectly accelerate aging by contributing to harmful behaviors that cause cell damage.
“Learning more about the aging process and the role of genetics in it may help us identify individuals early in life who may be at risk of unhealthy behaviors during adolescence or who may be prone to faster aging and related diseases later in life,” concludes senior author Elina Sillanp, Associate Professor at the Gerontology Research Center, University of Jyvskyl.
“Early identification of at-risk individuals may allow earlier intervention to change behaviors and prevent poor health outcomes later in life.”
Source: Eurekalert
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