So Long, Medical Scrubs. Jesse Williams Is Ready to Play Ball.

Which explains why, a few years ago, the director Scott Ellis offered him the role of Darren. Ellis had wanted to revive “Take Me Out,” which received the Tony Award for best play in 2003. But first he had to find a biracial leading man (Darren’s race is a crucial element of the play) of overwhelming charisma who could also pass as a Hall-of-Fame-level player. Having seen Williams on “Grey’s,” Ellis suspected that he could command a Broadway stage.

“It’s always that question,” Ellis said, speaking on a rehearsal break. “Can an actor cross the footlights? I thought, I bet he can.”

Williams turned Ellis down. His schedule on “Grey’s” — as an actor and occasional director — didn’t allow a Broadway run. The play itself, with its rhythmic, cerebral dialogue and its nude scene, scared him. But the offer nagged at him. And as his work on “Grey’s” began to feel, in his words, “increasingly safe, protected, insulated,” that fear became part of the appeal.

“I knew that as I designed my exit, the next thing I did had to be terrifying. I needed to get out of my comfort zone, I needed to go into a very unknown place,” he said. “Take Me Out” provided it.

REHEARSALS BEGAN in February 2020 and halted, as all Broadway did, that March. Williams spent the intervening months at home in Los Angeles, teaching the rudiments of baseball to his two children — he shares custody with his former wife, Aryn Drake-Lee — and intensifying his activism, particularly his support of the Black Lives Matter movement.

Williams sits on the board of the Advancement Project, an advocacy group devoted to civil rights. “He is deeply committed to racial justice,” said Judith Browne Dianis, its executive director. “He’s not one of the celebs or influencers that does things for his brand purposes. It’s deep in his soul.”