Shape of virus may determine RSV infection outcomes: Lab investigates shape-shifting protein in common respiratory virus
Respiratory syncytial virus, more commonly known as RSV, is a highly contagious respiratory virus that can be very serious and even fatal for young children and the elderly. In summer of 2021, health-care providers saw an unseasonable spike in the virus, which typically causes illness from October through March. While the virus has been recognized since the 1950s, there is no vaccine available.
Michael D. Vahey, a biomedical engineer at the McKelvey School of Engineering at Washington University in St. Louis, along with Jessica Kuppan and Margaret Mitrovich, both doctoral students in his lab and co-first authors of the paper, has developed a fluorescent system allowing him and his lab members to monitor the interactions between the virus particles and the proteins in the immune system that help to defend against infections, known as complement proteins. Through this system, they found that the viruses produced during RSV infection change shape — converting from long, rod-shaped particles to more rounded ones — and this makes a difference in whether the complement proteins are activated or not. Results of the work are published online in the journal eLife.
For RSV viruses to infect a cell, the membranes surrounding each of them have to fuse together through the action of the RSV F protein. Antibodies that bind to the F protein can prevent the virus from infecting cells. But the F protein is a well-known shape shifter, making it notoriously unstable, said Vahey, assistant professor of biomedical engineering, who studies infectious diseases.
“Ideally, we would like the immune system to target the form of F that can cause infection, but this doesn’t always happen,” Vahey said. “We found that when RSV changes shape from rods to spheres, the F protein tends to change shape, too. What we end up with is a situation where the virus particles that activate the complement system frequently have the wrong form of F on their surface. This may instruct the immune system to go after the wrong target.”
Vahey said the findings show that the biophysical properties of a virus, including its size and shape, matter in terms of how it is recognized by the immune system and may be important to consider when developing potential treatments or vaccines.
Story Source:
Materials provided by Washington University in St. Louis. Original written by Beth Miller. Note: Content may be edited for style and length.
For all the latest Health News Click Here
For the latest news and updates, follow us on Google News.
Denial of responsibility! NewsBit.us is an automatic aggregator around the global media. All the content are available free on Internet. We have just arranged it in one platform for educational purpose only. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, all materials to their authors. If you are the owner of the content and do not want us to publish your materials on our website, please contact us by email – [email protected]. The content will be deleted within 24 hours.
