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Scleroderma Pipeline Experiences Momentum: DelveInsight Estimates a Diverse Pipeline Comprising a Broad Spectrum of Molecular Targets

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Los Angeles, USA, Sept. 22, 2021 (GLOBE NEWSWIRE) — Scleroderma Pipeline Experiences Momentum: DelveInsight Estimates a Diverse Pipeline Comprising a Broad Spectrum of Molecular Targets

There are more than 50 companies that are developing therapies for the treatment of Scleroderma. Lenabasum (Corbus Pharmaceuticals) and Iloprost (Eicos Sciences) are in the most advanced stage (Phase III). Ongoing, Research and Development in the field of Scleroderma therapeutics are anticipated to bring a new effective therapy for the condition.

DelveInsight’s Scleroderma Pipeline Insights report lays down a holistic coverage of the available therapies, Scleroderma pipeline therapies in different developmental phases of clinical trials, key companies active in the Scleroderma pipeline domain, driving factors and restraints in the commercial launch of the Scleroderma pipeline therapies, and future trends. 

Some of the key highlights from the Scleroderma Pipeline report:

  • DelveInsight’s analysis depicts a robust Scleroderma Pipeline with 50+ active players in the domain working on 50+ pipeline therapies
  • Key Scleroderma pipeline therapies such as Lenabasum, EHP 101, FT011, Belumosudil, Guselkumab, ECCS 50, KHK4827, SAR156597, Treprostinil, HZN-825, GS-248, Brentuximab Vedotin, C21, ARG201, Belumosudil, CAM2043, Tofacitinib, Sarilumab, FCX 013, VIB7734, AVID200 and others are under evaluation in different phases of clinical trials for the treatment of Scleroderma. 
  • Corbus Pharmaceuticals, Emerald Health Pharmaceuticals, Gesynta Pharma, Formation Biologics, Fibrocell Science, CSL Behring, ChemomAb, Luminary Therapeutics, Certa Therapeutics, Kadmon Corporation, Janssen Pharmaceutical, Horizon Therapeutics, Acceleron Pharma, Tvardi Therapeutics, BriaCell Therapeutics, Blade Therapeutics, Biosplice Therapeutics, AnaMar, Immunemed, Viela Bio among several others are key prominent pharma companies working in the domain. 
  • In January 2021, Timber Pharmaceuticals received Orphan Drug Designation from U.S. FDA for TMB-003 for the Treatment of Systemic Sclerosis.
  • CiVi 030 is an intravenous formulation of iloprost, a potent vasodilator and platelet inhibitor with anti-inflammatory and anti-fibrotic effects being developed for the treatment of digital ischemic episodes in people with Systemic Sclerosis (SSc). CiVi 030 received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for the treatment of Systemic Sclerosis (SSc).
  • In April 2020, Horizon Therapeutics announced that it had acquired Curzion Pharmaceuticals and its development-stage oral selective lysophosphatidic acid 1 receptor (LPAR1) antagonist, CZN001 (renamed HZN-825), for the treatment of Systemic Sclerosis.
  • FCX-013 is being developed as a disease-modifying, autologous cell-based gene therapy that utilizes lentiviral vectors to deliver functional matrix metalloproteinase 1 genes (MMP-1) to patients with moderate to severe localized Scleroderma.
  • The U. S. Food and Drug Administration has granted Orphan Drug designation to FCX-013 for the treatment of localized Scleroderma. In addition, FCX-013 has been granted Rare Pediatric Disease designation and Fast Track designation for the treatment of moderate to severe localized Scleroderma.

Request for Sample to know which pharma company is expected to be at the forefront in the coming years @ Scleroderma Emerging Therapies and Forecast 

The Scleroderma Pipeline report comprises detailed information on ongoing clinical trials, deals, mergers & acquisitions taking place in the domain, recent approvals and failures in space, and growth prospects across the Scleroderma domain.

Scleroderma Overview

Scleroderma is a group of rare diseases that leads to the hardening and tightening of the skin and connective tissues. There are 2 major types of Scleroderma: Localized Scleroderma that affects the skin and Systemic Scleroderma that affects blood circulation and internal organs as well as the skin. The condition appears to affect women more as compared to men. At present, there exists no cure for the disease; however, there are symptomatic treatment approaches available. 

Discover more about the disease, treatments, and pipeline therapies @ Scleroderma Pipeline Assessment 

Scleroderma Pipeline Drugs 

Drug Company Phase MoA RoA
Lenabasum Corbus Pharmaceuticals III Cannabinoid receptor CB2 agonists Oral
Iloprost Eicos Sciences III Epoprostenol agonists Intravenous
KHK4827 Kyowa Kirin III Interleukin 17 receptor antagonists Subcutaneous
ECCS-50 Cytori therapeutics III Cell replacements Subcutaneous
EHP 101 Emerald Health Pharmaceuticals II Cannabinoid receptor CB2 agonists; Endothelial PAS domain-containing protein 1 inhibitors; Hypoxia-inducible factor 1 inhibitors; Peroxisome proliferator-activated receptor-gamma agonists Oral
FT011 Certa Therapeutics II Platelet-derived growth factor inhibitors Oral
Belumosudil Kadmon Corporation II Rho-associated kinase inhibitors Oral
Guselkumab Janssen Pharmaceutical II Interleukin-23 subunit p19 inhibitors Intravenous, Subcutaneous
FCX 013 Castle Creek Biosciences I/II Gene transference; Matrix metalloproteinase 1 replacements Intradermal
VIB7734 Viela Bio I Dendritic cell inhibitors NA
CM-101 Chemomab Therapeutics I Chemokine CCL24 inhibitors Intravenous
AM1476 AnaMar I Serotonin 2B receptor antagonists Oral
LMY-920 Luminary Therapeutics Preclinical Immunologic cytotoxicity; T lymphocyte replacements Parenteral
CAN-10 Cantargia Preclinical  Interleukin 1 inhibitors; Interleukin-33 inhibitors NA
hzVSF v13 ImmuneMed Discovery Immunomodulators; Virus replication inhibitors NA

Request for Sample to know more @ Scleroderma Pipeline Analysis, Key Companies, and Futuristic Trends 

Scleroderma Therapeutics Assessment 

The Scleroderma Pipeline report proffers an integral view of the Scleroderma emerging novel therapies segmented by Stage, Product Type, Route of Administration, Molecule Type, Target, and Mechanism of Action.

By Product Type

By Stage

  • Discovery 
  • Pre-clinical
  • Phase I
  • Phase II
  • Phase III

By Molecule Type 

  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy

By Route of Administration

  • Oral
  • Parenteral
  • Subcutaneous
  • Intravenous
  • Intradermal
  • Topical

By Mechanism of Action

  • Collagen inhibitors; Cytokine inhibitors
  • Dendritic cell inhibitors
  • Serotonin 2B receptor antagonists
  • Chemokine CCL24 inhibitors
  • Platelet-derived growth factor inhibitors
  • Gene transference; Matrix metalloproteinase 1 replacement
  • Cell replacements
  • Interleukin 1 inhibitors; Interleukin-33 inhibitors

By Targets

  • Proteins
  • Replication pathways

For rich insights into emerging therapies and assessment, visit Scleroderma Pipeline Emerging Novel Therapies 

Scope of the Scleroderma Drug Pipeline Report

Coverage: Global
Key Players: Corbus Pharmaceuticals, Emerald Health Pharmaceuticals, Gesynta Pharma, Formation Biologics, Fibrocell Science, CSL Behring, ChemomAb, Luminary Therapeutics, Certa Therapeutics, Kadmon Corporation, Janssen Pharmaceutical, Horizon Therapeutics, Acceleron Pharma, Tvardi Therapeutics, BriaCell Therapeutics, Blade Therapeutics, Biosplice Therapeutics, AnaMar, Immunemed, Viela Bio among others.
Key Scleroderma Pipeline Therapies: Lenabasum, EHP 101, FT011, Belumosudil, Guselkumab, ECCS 50, KHK4827, SAR156597, Treprostinil, HZN-825, GS-248, Brentuximab Vedotin, C21, ARG201, Belumosudil, CAM2043, Tofacitinib, Sarilumab, FCX 013, VIB7734, AVID200 and several others. 

Discover more about the scope of the report @ Scleroderma Emerging Therapies, Treatments, and Ongoing Clinical Trials 

Table of Contents 

1 Report Introduction
2 Executive Summary
3 Scleroderma Disease Overview
4 Scleroderma Pipeline Therapeutics Comparative Analysis
5 Scleroderma Therapeutic Assessment
6 In-depth Commercial Assessment
7 Scleroderma – DelveInsight’s Analytical Perspective
8 In-depth Commercial Scleroderma Assessment
9 Scleroderma Collaboration Deals 
10 Late Stage Scleroderma Products (Phase III)
10.1 Lenabasum: Corbus Pharmaceuticals
11 Mid-Stage Scleroderma Products (Phase II)
11.1 EHP 101: Emerald Health Pharmaceuticals
12 Early Stage Scleroderma Products (Phase I)
12.1 VIB7734: Viela Bio
13 Pre-clinical and Discovery Stage Scleroderma Products
13.1 LMY-920: Luminary Therapeutics
14 Inactive Scleroderma Pipeline Products 
15 Key Scleroderma Products
16 Unmet Needs
17 Scleroderma Market Drivers and Barriers
18 Future Perspectives and Conclusion
19 Analyst Views
20 Key Scleroderma Companies
21 Appendix

Learn more about the report offerings @ Scleroderma Pipeline Therapies and Emerging Trends 

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.  Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.

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