Restless Legs and Opioids; Obesity Brain Changes; Parkinson’s Apple Watch

Opioids at low doses continued to have good efficacy in people with refractory restless legs syndrome over 2 years, longitudinal data showed. (Neurology)

In a mouse model, focused ultrasound-mediated liquid biopsy (sonobiopsy) released more tau proteins and neurofilament light chain into blood circulation than liquid biopsy without focused ultrasound. (Radiology)

Increased screen time in infancy was tied to attention and executive functioning outcomes at age 9 years. (JAMA Pediatrics)

Cortical thinning in obese patients was similar to cortical thinning in Alzheimer’s dementia and may be related to cerebrovascular disease, inflammation, hypertension, or diabetes, a cross-sectional study found. (Journal of Alzheimer’s Disease)

The FDA lifted the full clinical hold on IkT-148009, an investigational c-Abl tyrosine kinase inhibitor being studied in Parkinson’s disease, Inhibikase Therapeutics said.

Is monitoring Parkinson’s with an Apple Watch a good thing? (Annals of Neurology)

Brief exposure to diesel exhaust acutely impaired brain connectivity, a small trial showed. (Environmental Health)

Moderate-to-vigorous physical activity was associated with lower risk of developing mild cognitive impairment or dementia in older women. (Alzheimer’s & Dementia)

Artificial neural networks inspired by brain learning achieved better classification success rates than those achieved by deep learning. (Scientific Reports)

The Alzheimer’s Association ended its agreement to provide education and awareness information to Compassion & Choices, an end-of-life organization.

Cassava Sciences suggested its investigational agent simufilam may have efficacy in Alzheimer’s dementia based on data from an open-label phase II study.