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Propulsion of Malignant Mesothelioma Pipeline as Novel and Extensive Therapies Enter the Treatment Domain, Anticipates DelveInsight

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Las Vegas, USA, Oct. 13, 2021 (GLOBE NEWSWIRE) — Propulsion of Malignant Mesothelioma Pipeline as Novel and Extensive Therapies Enter the Treatment Domain, Anticipates DelveInsight

Malignant Mesothelioma is a rare growth of mesothelial cells strongly associated with asbestos exposure. Major pipeline molecules include durvalumab, pembrolizumab, tremelimumab, nintedanib, ADI-PEG 20, and MesoPher. Additionally, the development of novel therapies is going to introduce advanced treatment options.  

DelveInsight’s ‘Malignant Mesothelioma Pipeline Insight 2021’ report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, key companies working to advance the pipeline space, and future growth potential of the Malignant Mesothelioma pipeline domain. 

Some of the crucial points taken from the Malignant Mesothelioma Pipeline report:

  • DelveInsight’s Malignant Mesothelioma Pipeline analysis depicts the space with 25+ active players working to develop 25+ pipeline therapies. 
  • Major pharmaceutical companies that are developing potential drug candidates to improve the Malignant Mesothelioma treatment scenario include Momotaro-Gene, Polaris Group, Amphera, Vivace Therapeutics, MedImmune, TCR2 Therapeutics, Atara Biotherapeutics, Inhibrx, Eisai, Targovax, Merck & Co, Bayer HealthCare, SELLAS Life Sciences Group, CanBas, FKD Therapies, Virttu Biologics, MolMed, Ys Therapeutics, LIPAC Oncology, TCR2 Therapeutics, Hutchison Medipharma Limited, Clovis Oncology, Sanofi, Merck & Co., PharmaMar, Targovax and many others.
  • Key Malignant Mesothelioma pipeline therapies such as rAd-IFN, Pembrolizumab, ADI-PEG 20, MesoPher, MTG201, HMPL-453, SAR444245, Rucaparib, TC 210, iCasp9M28z T-cell, INBRX-109, VT3989, LEITP-1009, YS110, Gavo-cel, iCasp9M28z T-cell, Lurbinectedin, ONCOS-102 and others are under investigation in different phases of clinical trials.
  • Targovax initiated a randomized, phase I/II clinical trial combining ONCOS-102 with Pem-Cis in 31 patients, indicating that ONCOS-102 can activate the immune system and increase tumour infiltrating T-cells into Malignant Pleural Mesothelioma.
  • Sellas Life Sciences Group is evaluating Galinpepimut-S (GPS) for the treatment of Malignant Mesothelioma. It is an immunotherapy that targets the Wilms Tumor 1 (WT1) protein which is present and over-expressed in an array of hematologic malignancies and solid tumors. 
  • LIPAC is developing a new Liposomal Enhanced IntraThoracic Paclitaxel (LEITP) for the treatment of Malignant Pleural Mesothelioma utilizing the LiPax technology. Preclinical studies with LEITP-1009 are underway.
  • In July 2021, PharmaMar announced that the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA) has given its positive opinion for Orphan Drug Designation to Zepzelca (lurbinectedin) for the treatment of Malignant Mesothelioma. 
  • UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase.
  • Momotaro-Gene is evaluating MTG201, a novel investigational gene therapy with unique dual mechanisms of action capable of addressing a range of cancers. A Phase II clinical trial is being conducted at the Baylor College of Medicine in Houston, Texas.

Track which potential therapy is anticipated to take charge of Malignant Mesothelioma pipeline in the forthcoming years by requesting a sample @ Malignant Mesothelioma Emerging Therapies and Forecast 

The Malignant Mesothelioma pipeline report lays down detailed profiles of the pipeline assets,  inactive and dormant assets, comparative analysis of clinical and non-clinical stage Malignant Mesothelioma products, comprehensive assessment of driving and restraining factors, along with the opportunities and risks in the Malignant Mesothelioma pipeline landscape.

Malignant Mesothelioma Overview

Malignant Mesothelioma is a rare, incurable, asbestos-related cancer. It mainly affects the lining of the lung and chest cavity (pleura) or lining of the abdomen (peritoneum). In rare cases, mesothelioma tumors can grow in the linings of the heart (pericardium) or testes (tunica vaginalis).

There are 4 types of mesothelioma, each affecting a different area in the body. The four types are pleural mesothelioma, peritoneal mesothelioma, pericardial mesothelioma, and testicular mesothelioma.

Explore more about Malignant Mesothelioma pipeline therapeutics assessment @ Malignant Mesothelioma Pipeline Assessment 

Malignant Mesothelioma Pipeline Drugs

Drug Company Phase MoA RoA
rAd-IFN Trizell Ltd III IFNA2B expression stimulants NA
Pembrolizumab Merck & Co III Programmed cell death-1 receptor antagonists Intravenous
ADI-PEG 20 Polaris Pharmaceuticals II/III Arginine deiminase replacements Intramuscular
MesoPher Amphera II/III Immunostimulant Intradermal
MTG201 Momotaro-Gene II DKK3 expression modulators Intratumoural
HMPL-453 Hutchison Medipharma Limited II Type 1, 2, 3 1 fibroblast growth factor receptor antagonists Oral
SAR444245 Sanofi II Interleukin-2 replacements Intravenous
Rucaparib Clovis Oncology II Poly(ADP-ribose) polymerase 1, 2, 3 inhibitors Oral
TC 210 TCR2 Therapeutics I/II Immunologic cytotoxicity; T lymphocyte replacements NA
iCasp9M28z T-cell Bellicum Pharmaceuticals I/II Immunologic cytotoxicity; Programmed cell death-1 receptor antagonists; T lymphocyte replacements NA
INBRX-109 Inhibrx I TRAIL receptor 2 agonists Parenteral
VT3989 Vivace Therapeutics I Transcription factor inhibitors Oral
LEITP-1009 LIPAC Oncology Preclinical Proto-oncogene protein c-bcl-2 inhibitors NA

Request for Sample to know more @ Malignant Mesothelioma Pipeline Analysis and Key Companies

Malignant Mesothelioma Therapeutics Assessment

The Malignant Mesothelioma Pipeline report proffers an integral view of the Malignant Mesothelioma emerging novel therapies segmented by Stage, Product Type, Route of Administration, Molecule Type, and Mechanism of Action.

By Product Type

  • Mono
  • Combination
  • Mono/Combination

By Stage

  • Discovery 
  • Pre-clinical
  • Phase I
  • Phase II
  • Phase III
  • Pre-registration

By Route of Administration

  • Subcutaneous
  • Intravenous
  • Oral
  • Inhalation

By Molecule Type 

  • Gene therapy
  • Stem cell therapy
  • Small molecules

By Mechanism of Action

  • Protease inhibitors
  • Immunomodulatory
  • Immunologic cytotoxicity; Programmed cell death-1 receptor antagonists; 
  • Proto-oncogene protein c-bcl-2 inhibitors
  • TRAIL receptor 2 agonists
  • Transcription factor inhibitors
  • Type 1, 2, 3 1 fibroblast growth factor receptor antagonists
  • Interleukin-2 replacements
  • IFNA2B expression stimulants
  • Arginine deiminase replacements

Scope of the Malignant Mesothelioma Pipeline Report 

  • Coverage: Global 
  • Major Players: Momotaro-Gene, Polaris Group, Amphera, Vivace Therapeutics, MedImmune, TCR2 Therapeutics, Atara Biotherapeutics, Inhibrx, Eisai, Targovax, Merck & Co, Bayer HealthCare, SELLAS Life Sciences Group, CanBas, FKD Therapies, Virttu Biologics, MolMed, Ys Therapeutics, LIPAC Oncology, TCR2 Therapeutics, Hutchison Medipharma Limited, Clovis Oncology, Sanofi, Merck & Co., and others.
  • Key Malignant Mesothelioma Pipeline Therapies: rAd-IFN, Pembrolizumab, ADI-PEG 20, MesoPher, MTG201, HMPL-453, SAR444245, Rucaparib, TC 210, iCasp9M28z T-cell, INBRX-109, VT3989, LEITP-1009, YS110, Gavo-cel, iCasp9M28z T-cell, and several others.

Gain rich insights into emerging therapies @ Malignant Mesothelioma Pipeline Emerging Novel Therapies 

Table of Contents 

1 Introduction
2 Executive Summary
3 Malignant Mesothelioma: Overview
4 Pipeline Therapeutics
5 Malignant Mesothelioma: Late Stage Products (Pre-registration)
6 Malignant Mesothelioma: Late Stage Products (Phase III)
6.1 rAd-IFN: Trizell Ltd
7 Malignant Mesothelioma: Mid Stage Products (Phase II)
7.1 HMPL-453: Hutchison Medipharma Limited
8 Malignant Mesothelioma: Early Stage Products (Phase I)
8.1 INBRX-109: Inhibrx
9 Pre-clinical and Discovery Stage Products
9.1 LEITP-1009: LIPAC Oncology
10 Therapeutic Assessment
11 Inactive Products
12 Malignant Mesothelioma – Unmet Needs
13 Malignant Mesothelioma – Market Drivers and Barriers
14 Appendix
15 About DelveInsight

Discover more about the scope of the report @ Malignant Mesothelioma Treatments Therapies and Ongoing Clinical Trials 

Track and assess candidate’s clinical development journey here @ Profiling and Comparative Therapeutic Assessment

Related Reports

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DelveInsight’s, “Acute Myeloid Leukemia (AML) – Pipeline Insight, 2021,” report provides comprehensive insights about 100+ companies and 100+ pipeline drugs in Acute Myeloid Leukemia (AML) pipeline landscape. It covers the pipeline drug profiles, including clinical and non-clinical stage products, key companies including BioSight, GlycoMimetics, Novartis, Takeda, Menarini Group, ImmunoGen, Kartos Therapeutics, Plexxikon, Shijiazhuang Yiling Pharmaceutical, Oscotec, Ryvu Therapeutics, and several others.

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DelveInsight’s ‘Multiple Myeloma (MM)-Market Insights, Epidemiology and Market Forecast—2030’ report offers rich insights into current and emerging treatments, pipeline therapies, and key pharmaceuticals including GlaxoSmithKline, Bristol-Myers Squibb/Bluebird bio, Oncopeptides AB, Secura Bio, Sanofi, Janssen Biotech, Celgene, Pfizer (Array Biopharma), Chipscreen Biosciences, Merck, Regeneron Pharmaceuticals, AstraZeneca, MorphoSys AG/I-Mab Biopharma, and many others. 

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Case Study 

Pipeline Assessment

A United States-based pharmaceutical working in the cancer immunotherapy domain approached DelveInsight to assist in analyzing the current pipeline activity as well as R&D of T-Cell Receptor (TCR) products for cancer treatment. DelveInsight proceeded with assessment of the pipeline, clinical trial details, Funding/Collaboration/Partnership Analysis, and R&D in the TCR domain.

About DelveInsight

DelveInsight is a leading Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.  Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.

For more insights, visit Pharma, Healthcare, and Biotech News 


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