Propulsion of Glioma Clinical Trial Pipeline as Novel and Extensive 220+ Therapies Likely to Enter in the Treatment Domain | DelveInsight

New York, USA, May 17, 2023 (GLOBE NEWSWIRE) — Propulsion of Glioma Clinical Trial Pipeline as Novel and Extensive 220+ Therapies Likely to Enter in the Treatment Domain | DelveInsight

The glioma pipeline and clinical trial analysis report deliver important insights on ongoing research, clinical strategies, upcoming therapeutics, and commercial analysis.

DelveInsight’s ‘Glioma Competitive Landscape – 2023‘ report provides comprehensive global coverage of available, marketed, and pipeline glioma drugs in various stages of clinical development, major pharmaceutical companies working to advance the pipeline space, company assessment, comparative assessment, and future growth potential of the glioma competitive domain.

Key Takeaways from the Glioma Competitive Landscape Report

• Over 200+ glioma companies are evaluating 220+ glioma drugs in various stages of development, and their anticipated acceptance in the glioma market would significantly increase market revenue. 
• Key glioma companies such as Denovo Biopharma, AstraZeneca, Pfizer, Chimerix, Bristol-Myers Squibb, Orbus Therapeutics, Northwest Biotherapeutics, Day One Biopharmaceuticals, AiVita Biomedical, Ascletis Pharma Inc, Kazia Therapeutics, HebaBiz Biotech, Biohaven Pharmaceuticals, Vigeo Therapeutics, Hoffman-La-Roche, TVAX Biomedical, Laminar Pharmaceuticals, Kintara Therapeutics, Medicenna Therapeutics, Symphogen A/S, MimiVax, Incyte Corporation, Istari Oncology, Immunomic Therapeutics, Sanofi, Merck Sharp & Dohme LLC, Oblato, Inc., GlaxoSmithKline, NuvOx Pharma, Epitopoietic Research Corporation, AnHeart Therapeutics, DNAtrix, Arog Pharmaceuticals, CANbridge Pharmaceuticals, Jiangsu Hengrui Medicine, BPGbio, Inc., BioMimetix, CNS Pharmaceuticals, Ever Supreme Bio Technology, Chia Tai Tianqing Pharmaceutical Group, CytoVac, and others are evaluating new glioma drugs to improve the treatment landscape.
• Promising glioma pipeline therapies such as Enzastaurin, Selumetinib, Tofacitinib, ONC201, Opdivo, Eflornithine, DCVax-L, DAY101, AV-GBM-1, ASC40, Paxalisib, JP001, Troriluzole, VT1021, Vemurafenib, TVI-Brain-1, LAM561, VAL-083, MDNA55, Sym004, SurVaxM, Retifanlimab, PVSRIPO, LAMP-pp65-DC, Plerixafor, Pembrolizumab, OKN-007, Niraparib, NanO2, ERC1671, AB-218, DNX-2401, Crenolanib, CAN008, Camrelizumab, BPM 31510, BMX-001, Berubicin, ADCV01, Anlotinib, ALECSAT, and others are under different phases of glioma clinical trials.
• In February 2023, Kite, a Gilead Company, announced the completion of the previously announced transaction to acquire Tmunity Therapeutics (Tmunity), a clinical-stage, private biotech company focused on next-generation CAR T-therapies and technologies.
• In February 2023, Genenta Science entered into a development and manufacturing service agreement (MSA) with AGC Biologics S.p.A. to manufacture cell therapy lentivirus-based product for Genenta’s ongoing clinical programs. AGC Biologics offers end-to-end global viral vector and cell therapy development, manufacturing, and quality/regulatory services, supported by scientists with more than 30 years of knowledge and experience.
• In October 2022, ITM Isotope Technologies Munich SE announced the execution of an exclusive licensing option for LuCaFab (now ITM-31), a novel Targeted Radionuclide Therapy candidate for the treatment of malignant glioblastoma.
• In October 2022, VBI Vaccines Inc., and Agenus, announced a collaboration to evaluate the combination of VBI-1901 in primary glioblastoma (GBM) patients as part of the adaptive platform trial, INSIGhT.
• In September 2022, Foundation Medicine, Inc., a pioneer in molecular profiling for cancer, and Day One Biopharmaceuticals, a clinical-stage biopharmaceutical company, announced a collaboration to develop FoundationOne®CDx as a companion diagnostic for Day One’s lead investigational therapy, tovorafenib (DAY101). If tovorafenib, and Foundation Medicine’s companion diagnostic are approved, this would be the first companion diagnostic indication for FoundationOne CDx in pediatric oncology.
• In September 2022, Merck announced a collaboration agreement with licensing option with Nerviano Medical Sciences S.r.l. (NMS) for NMS-293. Under the current agreement, Merck will make early payments (up-front and option exercise fees) of up to US$65 million to NMS. Furthermore, NMS will receive payments for the achievement of certain development, regulatory and commercial milestones and tiered royalties on net sales by Merck. Upon exercise of the option, NMS will grant Merck the exclusive rights to research, develop, manufacture, and commercialize NMS-293.

Request a sample and discover the recent advances in glioma treatment drugs @ Glioma Competitive Landscape Report

Glioma Overview

Glioma is the most prevalent type of glial cell tumor of the central nervous system (CNS). Glial cells, which include astrocytes, oligodendrocytes, and ependymal cells, are the origin of brain cancer or glioma. Glioma symptoms are caused by the invasion or compression of neighboring central nervous system structures and an increase in intracranial pressure. Glioma patients commonly experience headaches, seizures, weakness in the arms, face, and legs, numbness, personality changes, speech issues, nausea, vomiting, visual loss, and dizziness. 

Glioma diagnosis begins with a review of the patient’s medical history, followed by physical and neurological examinations. The neurological exam assesses the patient’s vision, hearing, speech, strength, balance, coordination, reflexes, and other neurological characteristics. The two most common scans used to diagnose glioma are magnetic resonance imaging (MRI) and computed tomography (CT) are the two most common scans used to diagnose glioma. A biopsy is yet another technique used to detect a brain tumor.

Glioma treatment is individualized and may include surgery, radiation therapy, and chemotherapy. Glioma patients have a much higher rate of recurrence even after surgery. Despite recent breakthroughs in detecting and treating cancer, the prognosis for gliomas remains dismal, particularly for patients with malignant and aggressive gliomas.

Find out more about glioma treatment drugs @ Drugs for Glioma Treatment

Glioma Pipeline Analysis: Drug Profile

Opdivo: Bristol-Myers Squibb

Opdivo is a programmed death-1 (PD-1) immune checkpoint inhibitor that uses the body’s own immune system to help restore anti-tumor immune response. Opdivo’s leading worldwide research program is based on Bristol Myers Squibb’s scientific competence in Immuno-Oncology, and it encompasses a wide range of clinical trials in all stages, including Phase III, in a variety of tumor types. More than 35,000 patients have been treated as part of the Opdivo clinical trial program to date. The Opdivo trials have contributed to a better understanding of the potential significance of biomarkers in patient treatment, specifically how patients may benefit from Opdivo throughout the PD-L1 expression spectrum.

Eflornithine: Orbus Therapeutics

Eflornithine, also known as a-diflurormethylornithine (DFMO), selectively targets and irreversibly inhibits ornithine decarboxylase (ODC), an enzyme required for polyamine production, as well as the function of DNA and RNA.  In contrast to multi-targeted tyrosine kinase inhibitors already on the market or in research, eflornithine targets only one enzyme, ODC. Eflornithine has been proven in animal experiments to suppress the formation of malignant tumors, including intracerebral mid- and high-grade gliomas. Eflornithine has also been proven to improve the anti-tumor action of other chemotherapeutic drugs. Eflornithine oral solution improved survival in individuals with newly diagnosed and recurring anaplastic glioma in both single-arm and controlled, randomized clinical studies. Eflornithine’s primary and reversible side effects were diarrhea and hearing loss.

A snapshot of the Glioma Pipeline Drugs mentioned in the report:

Learn more about the emerging glioma pipeline therapies @ Glioma Clinical Trials

Scope of the Glioma Competitive Landscape Report 

• Coverage: Global 
• Key Glioma Companies: Denovo Biopharma, AstraZeneca, Pfizer, Chimerix, Bristol-Myers Squibb, Orbus Therapeutics, Northwest Biotherapeutics, Day One Biopharmaceuticals, AiVita Biomedical, Ascletis Pharma Inc, Kazia Therapeutics, HebaBiz Biotech, Biohaven Pharmaceuticals, Vigeo Therapeutics, Hoffman-La-Roche, TVAX Biomedical, Laminar Pharmaceuticals, Kintara Therapeutics, Medicenna Therapeutics, Symphogen A/S, MimiVax, Incyte Corporation, Istari Oncology, Immunomic Therapeutics, Sanofi, Merck Sharp & Dohme LLC, Oblato, Inc., GlaxoSmithKline, NuvOx Pharma, Epitopoietic Research Corporation, AnHeart Therapeutics, DNAtrix, Arog Pharmaceuticals, CANbridge Pharmaceuticals, Jiangsu Hengrui Medicine, BPGbio, Inc., BioMimetix, CNS Pharmaceuticals, Ever Supreme Bio Technology, Chia Tai Tianqing Pharmaceutical Group, CytoVac, and others
• Key Glioma Pipeline Therapies: Enzastaurin, Selumetinib, Tofacitinib, ONC201, Opdivo, Eflornithine, DCVax-L, DAY101, AV-GBM-1, ASC40, Paxalisib, JP001, Troriluzole, VT1021, Vemurafenib, TVI-Brain-1, LAM561, VAL-083, MDNA55, Sym004, SurVaxM, Retifanlimab, PVSRIPO, LAMP-pp65-DC, Plerixafor, Pembrolizumab, OKN-007, Niraparib, NanO2, ERC1671, AB-218, DNX-2401, Crenolanib, CAN008, Camrelizumab, BPM 31510, BMX-001, Berubicin, ADCV01, Anlotinib, ALECSAT, and others

• Company Analysis, Therapeutic Assessment, Pipeline Assessment, Inactive drugs assessment, Unmet Needs

Dive deep into rich insights for new drugs for glioma treatment, visit @ Glioma Drugs

Table of Contents

For further information on the glioma pipeline therapeutics, reach out @ Glioma Treatment Drugs

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