NYC Plan for Mentally Ill Homeless; Auvelity for Alzheimer’s Agitation; TikTok Harms

New York City Mayor Eric Adams (D) announced that the city will be involuntarily hospitalizing mentally ill homeless residents who appear to be a harm to others. (New York Times)

The once-monthly investigational paliperidone palmitate extended-release injectable (LY03010) was bioequivalent to the original initial dosing regimen of Janssen’s paliperidone palmitate (Invega Sustenna) in patients with schizophrenia, with desirable exposure levels achieved within the first week, Luye Pharma announced.

College students attending exclusively online classes during the COVID-19 pandemic experienced more psychological distress than those who had a mix of online and in-person classes. (JAMA Network Open)

The FDA gave the greenlight for Vistagen to continue its phase I trial of PH10, its investigational pherine nasal spray, for major depressive disorder with a newly optimized formula intended for standalone treatment.

The investigational oral NMDA receptor antagonist dextromethorphan-bupropion (AXS-05) significantly improved Alzheimer’s disease agitation versus placebo in the phase III ACCORD trial, Axsome Therapeutics announced. This agent was FDA approved under the name Auvelity in August for major depressive disorder.

In a Danish cohort of nearly 200,000 patients, 46.9% had at least one subsequent diagnosis that differed from their first psychiatric hospitalization diagnosis, with the biggest diagnostic variability seen for persistent delusional disorders, drug use-related mental and behavioral disorders, and acute or transient psychotic disorders. (The Lancet Psychiatry)

How are impoverished countries coping with the dearth of psychiatrists? (Vox)

An Iranian cluster randomized trial found that general practitioner training on managing common mental health problems among children wasn’t much help in improving scores on the Strengths and Difficulties Questionnaire in a low-resource setting. (JAMA Psychiatry)

A study looked into how TikTok has perpetuated potentially dangerous content that may contribute to eating disorders. (PLOS One)