Narrower Impella Indication; Better TAVR in 90-Year-Olds; Statin Prescribing Nudge

Vaccination against the flu showed mixed results for cardiovascular prevention in a large international trial. (The Lancet Global Health)

Dietary supplements with the strongest evidence for cardiometabolic benefits: omega-3 fatty acids, folic acid, and coenzyme Q10. Other micronutrient supplements had no effects or, in the case of beta-carotene, even increased risk, according to a systematic review. (Journal of the American College of Cardiology)

FDA updated its labeling for the Impella RP System to incorporate final post-approval study results and narrow the indication of temporary right ventricular support in people who have acute right heart failure or decompensation without the presence of profound shock, end organ failure, or acute neurologic injury.

Transcriptomic and proteomic profiling may identify heart failure patients who are capable of myocardial recovery on advanced heart failure therapies. (Circulation)

Transplants are down for eligible patients with heart failure, whereas people are staying alive for longer on left ventricular assist devices. Should more people receive these devices? (Annals of Thoracic Surgery)

FDA cleared the EchoGo Heart Failure artificial intelligence platform for diagnosis of heart failure with preserved ejection fraction, Ultromics announced.

When delays were anticipated in treatment for ST-segment elevation myocardial infarction, upfront reperfusion therapy and angioplasty was a good alternative to late percutaneous coronary intervention in the experience of an Australian center. (European Heart Journal)

Endovascular therapy for a large vessel occlusion stroke was cost-saving even for patients with mild pre-existing disability, the HERMES investigators found. (Stroke)

In Japan, nonagenarians undergoing transcatheter aortic valve replacement (TAVR) had better outcomes than in prior reports. (JACC: Asia)

Amgen says its novel bispecific GIPR antagonist and GLP-1 receptor agonist, AMG 133, helped obese people shed weight in a first-in-human study.

Office-based clinics have been able to provide peripheral vascular interventions with outcomes rivaling those at hospitals. Nationwide data suggest patient populations are different between the two settings. (Circulation; Cardiovascular Quality and Outcomes)

In teenagers with Marfan syndrome, an exercise intervention aiming for 10,000 steps a day for 6 months was associated with slower aortic root dilation. (Journal of the American Heart Association)

Prompted by pop-ups in the electronic health record and monthly feedback, primary care physicians increased their statin prescribing to eligible patients. (JAMA Cardiology)

High-risk patients with known atherosclerotic cardiovascular disease and diabetes revealed disproportionately less knowledge about the former in a questionnaire. (Clinical Cardiology)

A randomized trial came out inconclusive on whether stronger compression stockings are better at preventing post-thrombotic syndrome after deep vein thrombosis. (The Lancet Haematology)

Scientists from Cold Spring Harbor Laboratory in New York share research on the roles of mono-allelic gene expression and long non-coding RNAs in cardiac development.