Major TBI Tied to Dementia; ALS Drug Shows Promise in Japan; Selma Blair’s MS

Major traumatic brain injury was tied to incident dementia, a longitudinal study in Finland showed. (Neurology)

Neutrophil activation as part of an acute inflammatory pain response may protect against chronic pain. (Science Translational Medicine)

Ante-mortem plasma p-tau181 concentrations accurately differentiated brain donors with and without autopsy-confirmed Alzheimer’s disease. (Brain)

Ultrahigh-dose methylcobalamin slowed functional decline in patients with early-stage ALS, a study in Japan showed. (JAMA Neurology)

Night-to-night variation in sleep predicted day-to-day variation in cognition, mood, vigilance, and behavior among people with Alzheimer’s disease. (Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring)

MS patients taking rituximab (Rituxan) had better responses to Pfizer’s COVID-19 vaccine tozinameran (Comirnaty) if they had higher B cell counts. (JAMA Network Open)

A French court ordered Sanofi to pay up to €450,000 in damages to a family whose child has a form of autism after prenatal exposure to the epilepsy drug valproate (Depakine), saying the drugmaker did not inform patients about known side effects. (Endpoints News)

Hallmarks of concussions and head trauma were seen in post-mortem brains of muskoxen and other headbutting animals. (Acta Neuropathologica)

Genetic drivers of cognitive resilience to Alzheimer’s pathology varied by sex. (Brain)

An analysis of the phase II CENTAUR trial data showed sodium phenylbutyrate and taurursodiol (AMX0035) prolonged tracheostomy-free and ventilation-free survival and delayed first hospitalization in ALS. (Journal of Neurology, Neurosurgery, and Psychiatry)

In an excerpt from her new memoir, actress Selma Blair recalls the moment she learned she had MS. (The Guardian)