Illegal Diet Supplements for CVD; Lung Disease in OAC Users; Myocarditis Mechanism

FDA sent warnings to seven companies selling dietary supplements with unlawful claims of treating or preventing cardiovascular disease.

A study from Taiwan showed that there was an increased risk of interstitial lung disease in people using oral anticoagulants (OACs), specifically factor Xa inhibitors, including rivaroxaban (Xarelto), apixaban (Eliquis), and edoxaban (Savaysa), for atrial fibrillation. (JAMA Network Open)

Meanwhile, a meta-analysis upheld a link between use of angiotensin-converting enzyme inhibitors and lung cancer. (British Journal of Cancer)

Around 4% of ischemic heart disease deaths around the world can be attributed to the flu. (eClinicalMedicine)

Some types of heart disease could make a person vulnerable to age-related macular degeneration associated with subretinal drusenoid deposits. (BMJ Open Ophthalmology)

Low birth weight was associated with a higher risk of heart attacks in adulthood in the U.K. Biobank. (Heart)

At least one in 10 survivors of sudden cardiac arrest will have a recurrent event, many of them even after treatment for a reversible etiology. (Circulation: Arrhythmia and Electrophysiology)

Following autopsy-inconclusive sudden cardiac death, genetic testing may reveal concealed cardiomyopathy — in which malignant arrhythmia occurred before noticeable structural changes in the decedent’s heart — and optimize screening of relatives. (Journal of the American College of Cardiology)

Yet racial disparities exist in knowledge about genetic sequencing, as shown in patients with dilated cardiomyopathy. (JAMA Cardiology)

Potentially helpful for prognosis in acute heart failure: serial measurements of GDF-15, NT-proBNP, and troponin I. (Circulation: Heart Failure)

The left atrial volume index may predict rehospitalizations in heart failure with preserved ejection fraction. (Clinical Cardiology)

Cardiotoxic breast cancer therapies produce modest, if any, changes in right ventricular systolic function, according to the largest prospective cohort study on this to date. (JACC: CardioOncology)

The Evolut FX system for transcatheter aortic valve replacement achieves better commissural alignment compared with the older Evolut PRO+. (JACC: Cardiovascular Interventions)

Patients with acute coronary syndrome and low bleeding risk had less bleeding, no worse ischemic outcomes, and improved survival outcomes after de-escalating antiplatelets following percutaneous coronary intervention, a meta-analysis showed. (Circulation: Cardiovascular Interventions)

Better include serum uric acid in cardiovascular risk models, a study suggested. (European Journal of Preventive Cardiology)

Low-income countries reported trouble implementing guidelines from the European Society of Cardiology, often citing financial barriers. (European Heart Journal)

Once-daily dosing of an investigational aldosterone synthase inhibitor, MLS-101, reduced blood pressure in the phase II Target-HTN trial in people with resistant hypertension, Mineralys Therapeutics announced.

Scientists traced immunotherapy-related myocarditis back to a mechanism involving T cells recognizing the cardiac antigen α-myosin. (Nature)