FRIDAY, Feb. 10, 2023 (HealthDay News) — For patients with pretreated relapsed and refractory multiple myeloma, idecabtagene vicleucel (ide-cel), a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy, prolongs progression-free survival and improves response compared with standard regimens, according to a study published online Feb. 10 in the New England Journal of Medicine to coincide with the European Society for Blood and Marrow Transplantation and European Hematology Association CAR T-Cell Meeting, held from Feb. 9 to 11 in Rotterdam, Netherlands.
Paula Rodriguez-Otero, M.D., Ph.D., from Clínica Universidad de Navarra in Pamplona, Spain, and colleagues conducted an international, phase 3 trial involving adults with relapsed and refractory multiple myeloma who had received two to four regimens previously and had disease refractory to the last regimen. A total of 386 patients were randomly assigned to ide-cel and one of five standard regimens (254 and 132 patients, respectively).
People are also reading…
The researchers found that the median progression-free survival was 13.3 and 4.4 months in the ide-cel and standard regimen groups, respectively, at a median follow-up of 18.6 months (hazard ratio for disease progression or death, 0.49). A response occurred in 71 and 42 percent of patients in the ide-cel and standard regimen groups, respectively; complete response occurred in 39 and 5 percent, respectively. For overall survival, data were immature. Adverse events of grade 3 or 4 occurred in 93 and 75 percent of patients in the ide-cel and standard-regimen groups, respectively. Cytokine release syndrome occurred in 88 percent of patients who received ide-cel, and investigator-identified neurotoxic effects occurred in 15 percent.
“These findings provide potential support for the use of ide-cel in patients with triple-class-exposed relapsed and refractory multiple myeloma, a population with poor survival outcomes,” the authors write.
The study was partially funded by 2seventy bio and Celgene, a Bristol Myers Squibb company; Bristol Myers Squibb and 2seventy bio manufacture idecabtagene vicleucel.
For all the latest Health News Click Here
For the latest news and updates, follow us on Google News.
Denial of responsibility! NewsBit.us is an automatic aggregator around the global media. All the content are available free on Internet. We have just arranged it in one platform for educational purpose only. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, all materials to their authors. If you are the owner of the content and do not want us to publish your materials on our website, please contact us by email – [email protected]. The content will be deleted within 24 hours.
