The study looked at 75,322 people in France with an average age of 58. Of those, 8%, or 6,026, were exposed to formaldehyde during their working life. Their occupations included nurses, caregivers, medical technicians, workers in the textile, chemistry and metal industries, carpenters and cleaners.
Lifetime formaldehyde exposure was calculated with a tool used to estimate a person’s exposure to potential health hazards in different occupations. People were split into three equal groups according to their years of exposure to formaldehyde; low was considered six or fewer years, medium was seven to 21 years, and high was 22 or more years. Participants were also split into three groups according to their cumulative exposure, which is the total amount of formaldehyde a person is exposed to over their lifetime based on the probability, intensity and frequency of exposure.
Cognitive function was measured using seven common tests of word recall, memory, attention, reasoning and other thinking skills, to assess each domain and to come up with a global cognitive score.
After adjusting for age, sex, education and other factors, researchers found people who were exposed to formaldehyde on the job had, on average, a 17% higher risk of having thinking and memory problems compared to those who were not exposed. This was true in every type of cognitive function the researchers tested.
For example, one of the cognitive tests is to match symbols to numbers according to a key located on the top of the page. The subject copies the symbol into spaces below a row of numbers. In this study, the maximum possible score was 135. The group not exposed to formaldehyde had an average score of 66, compared to an average score of 63 in the group that was exposed to formaldehyde.
Workers with the highest cumulative exposure to formaldehyde had a 19% greater risk on average of having cognitive impairment compared to those who had not been exposed.
“The use of formaldehyde has decreased over the last few decades; however, our results highlight the fact that there are still thousands of people whose work exposes them to the chemical, and they may face the risk of cognitive impairment later because of it,” Letellier said.
The study does not prove that exposure to formaldehyde causes cognitive impairment, it only shows an association.
A limitation of the study is that it did not include self-employed or agricultural workers.
The study was supported by the French Agency for Food, Environmental and Occupational Health & Safety.
Learn more about cognitive decline at BrainandLife.org, home of the American Academy of Neurology’s free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life® on Facebook, Twitter and Instagram.
When posting to social media channels about this research, we encourage you to use the hashtags #Neurology and #AANscience.
The American Academy of Neurology is the world’s largest association of neurologists and neuroscience professionals, with over 36,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy.
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Source: Eurekalert
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