The new mechanism may be explored pharmacologically to formulate a novel target for drug development against tau pathology.
“The fact it is a druggable target is really exciting, and it is a new mechanism that wasn’t previously established,” says Gabrielle Zuniga, first author and an MD/PhD student in the South Texas Medical Scientist Training Program.
Novel Tau Mechanism
It was found that deficits in an RNA quality-control pathway nonsense-mediated mRNA decay was described as an early event, that occurred long before neuronal cell death in tau-mediated cell damage.
“Nonsense-mediated mRNA decay is a key step in the process by which genetic information is translated into proteins.” Impairment of this quality-control mechanism results in buildups of RNA and production of abnormal, dysfunctional proteins. “It has an absolutely detrimental effect,” says Zuniga.
The study thereby suggests that targeting a much earlier mechanism mRNA decay pathways rather than targeting a later disease process tau deposition may seem as a promising yet brilliant discovery against various tau pathologies that may aid in formulating novel therapies.
Source: Medindia
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