Are you a mosquito magnet? It’s because of how you smell

Vosshall, whose lab is at Rockefeller University, set out to find why some people seem to smell better to an A. aegypti mosquito than others.

Fortunately, nobody had to sit in a room full of mosquitoes to conduct this experiment. Instead, the researchers collected the natural scent from people’s skin by having them wear nylon stockings on their arms. They cut the stockings into two-inch pieces and placed two pieces of the fabric behind two separate trap doors in a clear plastic box where dozens of mosquitoes are flying around. The researchers would then open the traps and the insects would choose to either fly to the bait – the stockings – behind the first or the second door.

Vosshall said the researchers conducted a round-robin style tournament and counted each time an insect was drawn to a particular sample, much like points in a basketball game. One of the samples, described as being from “subject 33,” emerged as a favourite of the insects.

“Subject 33 won a hundred games,” Vosshall said. “They were totally undefeated. Nobody beat them.”

The study found that people like subject 33, who have higher levels of compounds called carboxylic acids on their skin, are more likely to be “mosquito magnets,” Vosshall said.

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All humans produce carboxylic acid through sebum, a waxy coating, on their skin. The sebum is then eaten by millions of beneficial microorganisms to produce more carboxylic acid. In copious amounts, the acid can produce an odour that smells like cheese or smelly feet, Vosshall said. That smell appears to attract the female mosquitoes on the hunt for human blood.

Notably, the nylon stockings used in the study didn’t actually smell like sweat, she said. The mosquitoes are incredibly sensitive to human odour and perfume or cologne can’t cover it up. The experiment was conducted over the course of three years, and the same people continued to appeal to mosquitoes, regardless of what they ate that day or whether they changed their shampoo, Vosshall said

“If you’re a mosquito magnet today,” Vosshall said, “you will be a mosquito magnet three years from now.”

The study didn’t answer why some people have more carboxylic acids on their skin than others. But, Vosshall said the composition of the skin microbiome is unique in every individual.

“Everybody has a completely unique village of bacteria living on their skin,” Vosshall said. “Some of the mosquito magnetism differences we’re seeing here may simply be the differences in types of bacteria.”

LJ Zwiebel, a professor at Vanderbilt University who was not involved in the research, said that while carboxylic acids are clearly implicated in the study, there’s no “single compound” that attracts mosquitoes. It’s probably a “cocktail” of different components that signals the mosquito to home in and bite, he said.

“The mosquito is a multimodal magnet that uses a lot of different signals,” Zwiebel said. The carboxylic acids are “one significant component but not the only one.”

For someone who doesn’t want to be bitten by mosquitoes, Zwiebel said his advice is to take a shower to cut down on “all these juicy compounds” that are on your skin, especially around your feet, with its “unique odours.”

Vosshall said the future lies in figuring out how to “manipulate” the odours that originate from the skin and, potentially, the bacteria living there. Scientists, for instance, may be able to develop a probiotic skin cream that interferes with or reduces the levels of certain byproducts, which could make a person less attractive to mosquitoes.

“Only when you understand what makes people a mosquito magnet can you begin to brainstorm ways to stop that,” Vosshall said.

Washington Post

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