Abuse-Deterrent ADHD Tx Flops; Grief Timeline; Fecal Transfer for Bipolar Disorder?

The investigational attention deficit-hyperactivity disorder (ADHD) treatment Adair — an abuse-deterrent formulation of immediate-release dextroamphetamine — flopped in the phase III SEAL trial, Vallon Pharmaceuticals announced.

In a nationally representative poll, more than one in four parents said their child ages 11 to 18 had seen a mental health specialist. “Regular check-ups are the best time for providers to discuss potential mental health concerns,” said Gary L. Freed, MD, MPH, of the University of Michigan, in a statement.

Exactly just how long does it take to grieve and when does it peak? (New York Times)

A new NIH study assessed over 350,000 posts and comments on Reddit, finding that most people who shared their experience of non-suicidal self-injury spoke about it in terms similar to that of a substance use disorder, including having cravings, building up a tolerance, and trying to get “clean.” (Journal of Behavioral Addictions)

In a cross-sectional study of 1,755 former professional U.S. football players, childhood family dysfunction was linked with dementia and poor neuropsychiatric health in adulthood. (JAMA Network Open)

A systematic review found a dearth of evidence on how psilocybin therapy may interact with other psychiatric medications and treatments. (Psychopharmacology)

A modeling study found that fatal overdose deaths in the U.S. exceeded forecasts by 12% — or 7,601 deaths — during the last 43 weeks of 2020. (JAMA Network Open)

New studies are testing the effects of fecal microbiota transplantation for bipolar disorder and depression. (IFL Science)

A Maryland-based oral surgeon was charged with “depraved heart” murder after allegedly supplying his girlfriend with addictive IV anesthesia that subsequently led to a fatal overdose. (Washington Post)