EXPLAINER: What’s known about sudden liver disease in kids

The illnesses have no known connection, although a possible link with a virus that can cause colds is being investigated. At least one child died and several others have required liver transplants.

Previously healthy children are suddenly developing hepatitis, or liver inflammation often caused by viruses. Jaundice, diarrhea and abdominal pain are among reported symptoms. Children aged 1 month to 16 years have been affected.

Most cases have occurred in Europe. The first U.K. cases were recorded in January. The Centers for Disease Control and Prevention said in a nationwide health alert last week that the first U.S. cases were identified in October in Alabama.

Hepatitis is usually caused by one of several contagious hepatitis viruses that have not been found in the affected children. Sometimes the disease is mild and requires no specific treatment. But severe cases require hospitalization and can lead to liver failure.

Authorities are uncertain what is causing the outbreak. Nine children in the Alabama cluster tested positive for adenovirus. Some types of the virus can cause colds but authorities are also looking at a version that can cause digestive problems. It is unknown whether that virus is a cause or is somehow contributing to the outbreak.

Cases have been reported in at least a dozen countries, including Denmark, England, France, Ireland, Israel, Italy, the Netherlands, Norway, Scotland, Spain, and the United Kingdom. In the United States, cases have also occurred in Illinois and North Carolina.

The CDC says all physicians should be on the lookout for symptoms and report any suspected case of what’s called hepatitis of unknown origin.

Follow AP Medical Writer Lindsey Tanner at @LindseyTanner.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.