Dementia-Napping Link; Childhood Experience and Cognition; Capturing Alpha-Synuclein

Excessive daytime napping and Alzheimer’s dementia appeared to have a bidirectional relationship. (Alzheimer’s & Dementia)

The FDA’s approval of the controversial Alzheimer’s drug aducanumab (Aduhelm) last year sparked an attempt to overhaul the accelerated approval pathway, which allows a drug to be marketed based on surrogate endpoints. (Axios)

Childhood adverse events were linked with dementia symptoms and poor neuropsychiatric health later in life among former NFL players. (JAMA Network Open)

A novel PET tracer called ACI-12589 captured images of alpha-synuclein in a living brain for the first time and distinguished multiple system atrophy from other alpha-synucleinopathies, AC Immune said.

People with Parkinson’s disease appeared to have a genetic signature of the disease in their memory T cells. (NPJ Parkinson’s Disease)

Psychotropic drugs were associated with a higher incidence of post-COVID dementia in older adults 1 year after hospitalization. (Frontiers in Medicine)

Tranexamic acid after acute intracerebral hemorrhage did not increase the prevalence or number of remote cerebral lesions on brain MRI, a substudy of TICH-2 trial data showed. (JAMA Neurology)

Most people who filled buprenorphine prescriptions written by emergency physicians did not subsequently fill these prescriptions written by other clinicians. (Annals of Emergency Medicine)

Physical activity was tied to slower cognitive decline in older adults with higher neurofilament light chain serum concentrations. (JAMA Network Open)

Plasma mRNA levels of Alzheimer’s-relevant genes boosted the predictive value of Alzheimer’s biomarkers in a study of African-American older adults. (eBioMedicine)