In addition, the activation of Na,K-ATPase oxidant amplification loop is also found to affect the expression of important protein markers in fat cells (adipocytes) as well as in the hippocampus (critical seat to memory and cognitive function). This worsens the brain function, thereby leading to neurodegeneration.
Hence, targeting the fat cells to antagonize Na,K-ATPase may improve these outcomes. The study team used a genetically modified mouse model that released the peptide NaKtide specifically in adipocytes, or fat cells, to validate their findings.
Effect of Diet
They also increased the production of inflammatory cytokines confined to adipocytes as well as altered protein markers of memory and cognition in the hippocampus by inducing oxidative stress through the western diet.
“Western diet induces oxidant stress and adipocyte alteration through Na,K-ATPase signaling which causes systemic inflammation and affects behavioral and brain biochemical changes. Our study showed that adipocyte-specific NaKtide expression in our murine model ameliorated these changes and improved neurodegenerative phenotype,” says Komal Sodhi, M.D., first author and associate professor of surgery and biomedical sciences at the Joan C. Edwards School of Medicine.
Source: Medindia
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